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BECKMAN COULTER

> phi (Prostate Health Index) p2PSA
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Prostate Cancer Detection: How to Make PSA a Better Marker Question can be answered with a simple blood test ?
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prostatehealthindex.org/

 What  is the new p2PSA test and phi?

p2PSA
Researchers have identified several isoforms of free PSA which are precursor forms of PSA, called proPSA. The [-2]proPSA form was determined to be the most specific for prostate cancer (PCa). The new Access Hybritech p2PSA test measures the concentration of [-2]proPSA in serum.

p2PSA and phi
The Hybritech p2PSA immunoassay is used in conjunction with the Access Hybritech PSA and free PSA to calculate the patient's personalized prostate cancer risk assessment, also known as the Prostate Health Index, or phi.1,2,3

phi is not a replacement for PSA testing, but a tool to provide better specificity for detecting prostate cancer than testing for PSA and % free PSA alone. The phi result will help to better determine if a man, suspected of having prostate cancer (e.g. with a PSA between 2.0 and 10 ng/mL), should be recommended for a prostate biopsy.

Studies have demonstrated that when p2PSA measurements are combined with Access Hybritech PSA and free PSA measurements, the resulting index demonstrates a significant improvement in clinical specificity for prostate cancer detection, relative to PSA and % fPSA alone, in the PSA range 2-10 ng/mL in men 50 years of age or older and with non-suspicious digital rectal exam (DRE) findings.

 

BECKMAN COULTER website
BECKMAN COULTER
Solutions and systems for clinical diagnostics (hematology, biochemistry, immunoassays, flow cytometry. Solutions for industry & research, for genetics, proteomics and cellular analysis. Lab automated workstation & liquid handling workstation.
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