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ANALIS

CE-MS Sprayer

A simple way to combine advantages of CE and MS in a single run ?
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DESCRIPTION
A simple way to combine advantages of CE and MS in a single run ?

The ANALIS SL CE-MS Sprayer is a simple microfluidic Capillary Electrophoresis-ElectroSpray Ionization-Mass Spectrometric detection interface (CE-ESI-MS) using (sub) microliter flow of Sheath Liquid (SL).

This new CE-MS interface has been developped by ANALIS R&D and  the Mass Spectrometry laboratory of University de l’ULg - GIGA-R - Professor Edwin De Pauw*. This projet was partially supported by the Walloon Region (FIRST Enterprise Project 6592).


Capillary Electrophoresis (CE) & Mass Spectrometry (MS) are two powerful analytical techniques where analytes placed in an electrical field are separated based on their charge and mass ratio, i.e. the electrophoretic mobility (μ) of ions for CE and m/z ratio for MS.

The main difference is that one takes place in a liquid phase and the other in vacuo (gas phase). CE-MS combines advantages of CE and MS to provide high resolving power, molecular mass information and structural elucidation in a single run. The ElectroSpray Interface (ESI) will ionize the analytes, allowing the transfer of charged analytes from a liquid phase to the gas phase. The ionized analytes will then be injected into the MS for further analysis. To ionize the analytes after the CE separation, an additional electrical potential is applied between the outlet of the capillary and the inlet of the MS. A typical Taylor cone covering the outlet side of the CE capillary pulls the liquid phase coming from the sheath liquid channel as well as the analytes eluted from the CE. The Taylor cone (formally the cone jet) will further generate smaller and smaller droplets, ended up with charged molecules in gas phase. This emitter needle is designed to allow sub-microliter flow rate (below 1μL/min) of sheath liquid.

The advantage of low flow rate is to prevent dilution of the sample, while the sheath liquid may be optimized for optimal ionization of the analytes inside the ElectroSpray Interface

Read more : download CE-MS Brochure


* Mass Spectrometry Laboratory Department of Chemistry University of Liège Institut de Chimie, Bat. B6c B-4000 Liège (Sart-Tilman)Director : Prof. Edwin De Pauw Tel : (32)-4-366.33.70 (or 34.33) Fax : (32)-4-366.34.13

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Prices are quoted in euro (taxes excluded) and apply in the Benelux (recycling fee included). They are subject to change without notice. We reserve the right to adjust pricing errors and to limit quantities.

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